RMalert was created as a response to the lack of user-friendly yet scientifically advanced tools for analysis of planned test compounds regarding risk of RM formation. Understanding goes through past experience and a wealth of reviews repeatedly list the same examples where the chemical reactions leading to reactive intermediates have been reasonably well established. The offending substructures of these examples can be learnt, and knowledge applied, but judging from the many recently published test compounds the knowledge is used within wide frames.
RMalert functions by linking a large set of structural alerts to the important drugs that have the same feature, either they have shown ADEs associated with RMs (“red” or “yellow” drugs)or not (“green” or “neutral” drugs). Criteria for categorization here.
When it comes to more subtle warning signals that, which are less detailed in the reviews, RMalert proves its strength by providing large sets of specifically substituted aromatics as alerts. These are linked to the important drugs that have the same feature either they have shown ADEs associated with RMs or not.
Regarding not established reaction mechanisms RMalert challenges your chemistry understanding by including speculations and hypotheses of what might be occurring.
Finally, we strive to make RMalert the best tool for its purpose and RMalert is constantly evolving to reach that goal.