SpotRM+1.1 is here! A downloadable DEMO version is available. Try this >>

Welcome to learn more about

reactive metabolites

a tool that helps you avoid the test substances that have issues regarding
reactive metabolites

SpotRM+ is a novel expert tool that supports your decisions of new drug structures by warning of potential problems with reactive metabolites. Running locally on your PC using the Bioclipse platform, SpotRM+ highlights potential hazards in your structure by matching it with a set of carefully selected structural alerts (SA). The importance of deselecting potentially hazardous structures is discussed in our White Paper.

(The site stoprm.org contains a large number of links to reviews and presentations on awareness/avoidance of reactive metabolites (RM) in drug design.)

KEY FEATURES

  • The application uses 60+ structural alerts (SA).
  • Many SAs go beyond the commonly recognized ones.
  • Real drug examples (270+)illustrate the links between SAs and adverse effects.
  • Background is explained in concise summaries that are extensively crosslinked.
  • Large selection of links to web-based information, such as literature references, LiverTox db, DailyMed, and more.
  • Micro-reviews that put most common RM mechanisms into context.
  • Free DEMO version is available

 

The most prominent feature of SpotRM+ is the wealth of information linked to each alert, some of which is bound to be new to you and may well be an eye-opener.

In summary, SpotRM+ is a unique expert database that delivers:

  • A comprehensive compilation of structural features that are believed to be involved in the clinical symptoms of problem drugs.
  • Unprecedented, easy access to the most relevant information on structural alerts and reported evidence of their involvement.

SpotRM+ is a plug-in to the Bioclipse platform, which also features a number of other plug-ins useful in drug design and ADMET work.

Below is a brief outline of the search and display functionalities which, however, does not show the latest functions for key-word, substructure and similarity searches. Watch the video to see these.


SpotRM+

Basic Usage

Installation


 

reactive metabolites

reactive metabolites